1. Dosing Flexibility: You should receive the precise amount of medication that you require. You can adjust the dose of SCOPACE for your individual needs. In contrast, the patch provides only a fixed dose. One fixed dose may not be appropriate for all people. Generally, a larger person requires more medication than a smaller person.

2. Greater Efficacy: Oral scopolamine was twice as effective as topical in preventing motion sickness in a study conducted for NASA.² A separate study reported that motion-induced symptoms decreased 75% with oral scopolamine but only 63% with topical scopolamine.⁸ Scopolamine was not absorbed well across the skin in 29% of patients tested.³ Indeed, variable absorption and possible underdosage of large patients may have contributed to the report that topical scopolamine is effective in relieving motion sickness, sea sickness in only 50-74% of users.³

3. Lower Incidence of Side Effects: Common side effects associated with topical scopolamine include dry mouth (occurring in about two-thirds of people) and drowsiness (occurring in less than one-sixth of people).⁴ The occurrence of side effects was reported as more frequent with topical scopolamine when compared with an equivalent tablet dose.⁵ Side effects may be minimized with the dosing flexibility available with SCOPACE: take the lowest dose needed to achieve the desired travel comfort.

4. Faster Onset of Action: SCOPACE dissolves within minutes for quick GI absorption and onset of effect. In contrast, effective drug concentration is not achieved until some 6-8 hours after the patch is applied.⁶

5. Shorter Duration of Action: With its duration of approximately 8 hours, SCOPACE is well suited for short periods of travel. It can also be considered for longer periods of travel during which one may acclimate to the motion and need less medication over time.

6. Cost Effective: One dose of SCOPACE is less than 10% of the cost of a scopolamine patch.⁷ SCOPACE is very cost-effective and covered by most health insurance plans -- making its cost reimbursable or limited to only a modest co-payment.

Fear of motion sickness, Sea Sickness should not disrupt travel plans. Please share this with your doctor and ask whether SCOPACE is appropriate for your travel comfort.

REFERENCES

1. AHFS Drug Information 1996. American Hospital Formulary Service
2. Wood, M.J. et al Comparison of Dosage Routes for Antimotion Sickness Drugs. Aviation, Space, and Environmental Medicine. May 1987; 504.
3. Doweck, I. et al. Rate of Absorption of Scopolamine After Application of Scopoderm-TTS. Aviation, Space, and Environmental Medicine. May 1994; A24.
4. Advertisement. CIBA Pharmaceuticals.
5. Parrott, A.C. The Effects of Transdermal Scopolamine and Four Dose Levels of Oral Scopolamine (0.15, 0.3, 0.6, and 1.2 mg) Upon Psychological Performance. Psychopharmacology. 1986. 89: 3; 347-354.
6. Dobie, T.G. and May, J.G. Cognitive-Behavioral Management of Motion Sickness. Aviation, Space, and Environmental Medicine. October 1994; C1-C20.
7. 1998 Redbook. Medical Economics Company. Oradell, New Jersey.
8. Graybiel, A. et. al. Prevention of Experimental Motion Sickness by Scopolamine Absorbed through the Skin. Aviation, Space, and Environmental Medicine. 1976; 47: 1096.